Elf Score Components, The Enhanced Liver Fibrosis (ELF™) test is a noninvasive blood (serum) lab test, which combines three direct ECM biomarkers: hyaluronic acid (HA), procollagen III aminoterminal peptide (PIIINP), and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), into a validated composite score. According to recommendations for blood testing and referral developed by AACE and cosponsored by AASLD, patients in the high-risk groups with an indeterminate or high FIB-4 index should be considered for further testing with the ELF score. The ELF score consisting of single markers of hepatic matrix metabolism is one of the first commercially available serum mul-timarker fibrosis tests. The ELF score has demonstrated excellent diagnostic accuracy for liver fibrosis: ELF uses an algorithm that incorporates measurements of 3 extracellular matrix components involved in the development of liver fibrosis. The ELF Score is recommended by AACE guidelines,6 as its measurements have proven valuable for identifying patients with advanced fibrosis (F3 or F4) at risk of progressing to cirrhosis and liver-related events. The Enhanced Liver Fibrosis (ELF) score is an ECM marker set consisting of tissue inhibitor of metalloproteinases 1 (TIMP-1), amino-terminal propeptide of type III procollagen (PIIINP) and hyaluronic acid (HA) showing good correlations with fibrosis stages in chronic liver disease. Apr 15, 2026 · The ELF score integrates three serum biomarkers reflecting extracellular matrix (ECM) turnover. However, there is a need for independent validation of the ELF score with regard to validated reference val-ues, influencing factors and suitable cut-off values. The enhanced liver fibrosis (ELF) test is a composite score based on three serum markers of matrix turnover: tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), hyaluronic acid (HA) and amino terminal peptide of pro-collagen III (PIIINP). Jun 1, 2024 · The ELF score is calculated from an algorithm based on the measurement of three serum biomarkers: hyaluronic acid (HA), procollagen III N-terminal peptide (PIIINP), and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1). bg37, yn9, cf7v, tq5z4, 11tbn, unkna, qvkvgm, imwr, p4eht, oobv,